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KMID : 0043320130360091084
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Archives of Pharmacal Research
2013 Volume.36 No. 9 p.1084 ~ p.1089
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Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis
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Cheng Jin Tang
Han Ya Qiong
He Juan
Wu Xing De
Dong Liao Bin
Peng Li Yan
Li Yan
Zhao Qin Shi
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Abstract
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Two new tirucallane triterpenoids, aquilacallanes A?B (1?2), together with 15 known compounds (3?17) were isolated from the leaves of Aquilaria sinensis. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activity against five human cancer cell lines. The known compounds, ursolic acid (7) and 5,7,4′-trimethoxyflavone (14), exhibited weak cytotoxic activity against some cells.
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KEYWORD
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Aquilaria sinensis, Tirucallane triterpenoids, Aquilacallanes A?B, Cytotoxic activity
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